Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
175 mcg
875%

Top Medical Research Studies

9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
Read More
8
Vitamin D associated with cholesterol improvement
Our investigation centered around the link between vitamin D levels and cholesterol, particularly focusing on high cholesterol. We analyzed data from nearly 48,000 outpatients to see how two forms of vitamin D—25-hydroxyvitamin D and 1,25-dihydroxyvitamin D—relate to various cholesterol parameters, such as LDL (the "bad" cholesterol), HDL (the "good" cholesterol), and total cholesterol levels.

We discovered that higher levels of 25(OH)D are connected with lower LDL and total cholesterol levels across the board. This relationship was especially strong among men over 50. Interestingly, the pattern varied for women; they showed a positive correlation with LDL and total cholesterol before age 50, but a negative association afterwards.

HDL levels consistently improved with higher 25(OH)D levels in all age groups, demonstrating the strongest link in postmenopausal women. However, the other form, 1,25(OH)D, only positively associated with HDL in people over 50 and didn't show significant effects on LDL or total cholesterol in any age category.

Overall, we pointed out that elevated levels of 25(OH)D can contribute to better cholesterol profiles, marked by lower levels of LDL and total cholesterol as well as higher HDL levels. This effect was particularly notable in those over 50 and postmenopausal women, highlighting the potential role of vitamin D in managing cholesterol levels.
Read More

Most Useful Reviews

9
High level attained
1 people found this helpful
I was significantly below the required vitamin D levels, but this product raised my level to the high side within three months. I've since reduced the dosage, as I reached my target.
Read More
7.5
Vitamin D improvement
2 people found this helpful
I've been taking the capsules daily for 2 ½ months, and my vitamin D level has never been higher at 79.8 ng/ml. I can now space out the doses to every other day to maintain this level. I don't sunbathe, and I've never achieved this result with the vitamin D sold here in Brazil. Thank you for this wonderful product!
Read More
7.5
Effective choice
I liked taking Life Vanek vitamins daily. When my doctor prescribed a high dosage of vitamin D at 7000, I chose these capsules. They are effective, but such high dosage should not be self-prescribed as it is therapeutic.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
  • All Researches
9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.

Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.

Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.

In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Read More
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.

Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.

Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.

Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
Read More
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
Read More
8
Ergosterol may improve cholesterol levels
We explored how ergosterol, a precursor of vitamin D, impacts cholesterol levels and vitamin D biosynthesis in ovariectomized (OVX) rats. Our study revealed that daily high ergosterol intake over 14 weeks significantly lowered plasma cholesterol levels, an important finding since high cholesterol can lead to various health issues.

Additionally, we found that treated OVX rats had higher levels of 7-dehydrocholesterol, a precursor to vitamin D, suggesting that ergosterol not only helps decrease cholesterol but may also promote improved vitamin D synthesis. We also observed a slight increase in the active form of vitamin D in these rats.

Perhaps most excitingly, ergosterol contributed to better bone strength, countering some of the effects of OVX-induced bone resorption. This suggests that ergosterol could be a promising option for addressing both dyslipidemia and osteoporosis in postmenopausal women, providing a dual benefit for health.

Overall, our findings support the idea that ergosterol could be an adjunct to traditional treatments for managing cholesterol and promoting vitamin D levels.
Read More

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
High level attained
1 people found this helpful
I was significantly below the required vitamin D levels, but this product raised my level to the high side within three months. I've since reduced the dosage, as I reached my target.
Read More
7.5
Vitamin D improvement
2 people found this helpful
I've been taking the capsules daily for 2 ½ months, and my vitamin D level has never been higher at 79.8 ng/ml. I can now space out the doses to every other day to maintain this level. I don't sunbathe, and I've never achieved this result with the vitamin D sold here in Brazil. Thank you for this wonderful product!
Read More
7.5
Effective choice
I liked taking Life Vanek vitamins daily. When my doctor prescribed a high dosage of vitamin D at 7000, I chose these capsules. They are effective, but such high dosage should not be self-prescribed as it is therapeutic.
Read More
7.5
Scarcity addressed
1 people found this helpful
This product is very good and definitely effective. Vitamin D is a scarce nutrient; the normal blood level is 30 to 100 ng/ml, yet many do not exceed 30. There are few products dosage-wise between 5000 and 10,000 units, and this one seems just right—especially for Life Extension.
Read More

Frequently Asked Questions

9
High level attained
1 people found this helpful
I was significantly below the required vitamin D levels, but this product raised my level to the high side within three months. I've since reduced the dosage, as I reached my target.
7.5
Vitamin D improvement
2 people found this helpful
I've been taking the capsules daily for 2 ½ months, and my vitamin D level has never been higher at 79.8 ng/ml. I can now space out the doses to every other day to maintain this level. I don't sunbathe, and I've never achieved this result with the vitamin D sold here in Brazil. Thank you for this wonderful product!
7.5
Effective choice
I liked taking Life Vanek vitamins daily. When my doctor prescribed a high dosage of vitamin D at 7000, I chose these capsules. They are effective, but such high dosage should not be self-prescribed as it is therapeutic.
7.5
Scarcity addressed
1 people found this helpful
This product is very good and definitely effective. Vitamin D is a scarce nutrient; the normal blood level is 30 to 100 ng/ml, yet many do not exceed 30. There are few products dosage-wise between 5000 and 10,000 units, and this one seems just right—especially for Life Extension.
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.

Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.

Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.

Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.

References

  1. Liu ZY, Liu S, Yao X, Wang CY, Song Y, et al. A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults. Front Nutr. 2024;11:1492621. 10.3389/fnut.2024.1492621
  2. Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. 10.1093/nutrit/nuae226
  3. Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
  4. Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. 10.1615/CritRevImmunol.2024052129
  5. Li X, Liu Y, Wang J, Chen X, Reichetzeder C, et al. Vitamin D Is Associated with Lipid Metabolism: A Sex- and Age-Dependent Analysis of a Large Outpatient Cohort. Nutrients. 2024;16. 10.3390/nu16223936
  6. Hu T, Zhang Y, Chen Z, Su J. Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018. Front Nutr. 2024;11:1468284. 10.3389/fnut.2024.1468284
  7. Xu H, Qiu S, Lin P, Liao X, Lin Y, et al. Vitamin D has therapeutic effects on obesity and hyperandrogenemia in PCOS mouse model induced by low dose DHEA and high-fat diet. BMC Womens Health. 2024;24:601. 10.1186/s12905-024-03445-w
  8. Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
  9. Wang J, Shi T, Xu L, Li Y, Mi W, et al. Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort. Front Nutr. 2024;11:1302260. 10.3389/fnut.2024.1302260
  10. Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
  11. Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. 10.3390/nu16091331
  12. Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. 10.1007/s11033-024-09408-6
  13. Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. 10.1080/10790268.2023.2257850
  14. Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. 10.1139/cjpp-2022-0359
  15. Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. 10.3390/nu15071645
  16. Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. 10.3389/fphar.2023.1135516
  17. Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. 10.3390/life13020581
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